Learn about Erectile Dysfunction and Sildenafil Citrate Online

Have you ever wondered how sildenafil acts within your body to help you solve your problems with erectile dysfunction?  Thanks to the instant availability of the Internet and computer devices, you will now be able to learn about ED and sildenafil citrate online right at your fingertips.

If you are curious as to how PDE5 inhibitors such as sildenafil work inside your body, then you can browse on search engines by simply typing in the search box the words sildenafil citrate online.  When you read about the mechanics of the action of sildenafil citrate online, you will learn that it helps protect the enzyme cGMP (short for cyclic guanosine monophosphate) from being degraded by the cGMP-specific PDE5 (short for phosphodiesterase type 5 enzyme) which are evidently located in the penile corpus cavernosum of men.  The free radical NO (short for nitric oxide) found in the penile corpus cavernosum adheres itself to what are called the guanylate cyclase receptors, which then results to the occurrence of elevated amounts of cGMP, thereby leading to the vasodilation or relaxation of the smooth muscles of the inner lining cushions of the helicine arteries (tendril-like arteries of the penis importantly involved in the process of its erection).  Once the smooth muscles relax, it will result to vasodilation and therefore there will be an increased supply of blood flowing into the penile spongy tissue, and the end result would be a successful penile erection.

Additionally, what you would also learn about sildenafil citrate online is that its special molecular makeup is somewhat similar to cGMP (located in the penile corpus cavernosum as well) and functions as an aggressive binding element of PDE5 in the penile corpus cavernosum, which results to more concentrations of cGMP and even better occurrences of erections. Avery important information that men will learn through reading about sildenafil citrate online is that sildenafil will be rendered useless without the introduction of one or more sexual stimuli, since only a sexual stimulus will be the only factor that can initiate the activation of the nitric oxide and cGMP inside a man’s body. Read more…

What's in the news: Nov. 12 -- Addictions MDs oppose mandatory minimums

Addictions physicians oppose mandatory-minimum sentencing
The Centre for Addiction and Mental Health, based in Toronto, announced its opposition to Bill C-15, federal legislation that would create mandatory-minimum sentences for drug crimes. "The evidence from the U.S. and other jurisdictions tells us that mandatory minimum sentences are most effective at increasing prison populations and the cost of jailing them," CAMH deputy director Wayne Skinner told a Senate committee. "Reducing the demand for illicit drugs by investing in addiction treatment, including drug treatment courts, have proven to be much more cost effective and successful approaches." The bill was passed earlier this year by the House of Commons and is now before the Senate.

Oil-sands whistleblower MD found guilty of ethics charges
The results of the College of Physicians and Surgeons of Alberta's investigation, recently leaked to the media, showed Dr John O'Connor, who made international news when he claimed to have found multiple cases of a rare bile-duct cancer in a First Nations community near the oil development sites in Alberta, violated his professional ethics code by refusing to cooperate with the investigation and, moreover, "made a number of inaccurate or untruthful claims with respect to the number of patients with confirmed cancers and the ages of patients dying from cancer."

Quebec party's health point-man goes independent
Éric Caire, who was the Quebec ADQ party's health critic before losing a leadership contest by two votes just three weeks ago, has decided to leave the party and sit as an independent. The man who defeated Mr Caire in the leadership race, Gilles Taillon, has already announced he is stepping down and said he would likely contact the Quebec provincial police about suspected financial crimes within the party. This leaves the future uncertain for a party that just a couple of years ago was the official opposition in Quebec City and played a major role in advancing the debate on health-insurance reform in Quebec. "Is it RIP for the ADQ?" asked the Montreal Gazette.

The state of evidence-based medicine
"To enter mainstream use, any... treatment typically needs to clear a high bar. It will be subject to randomized trials, statistical-significance tests, the peer-review process of academic journals and the scrutiny of government regulators," writes journalist David Leonhardt in a new piece on evidence and intuition in medicine. "Yet once a treatment enters the mainstream — once we know whether it works in certain situations — science is largely left behind. The next questions — when to use it and on which patients — become matters of judgment, not measurement."

eBay's more profitable than medicine
An American FP took time off from her medical practice when she gave birth to twin girls and discovered she could make more money selling clothing on eBay -- $120,000 last year -- than she could working full-time as a doctor.

Photo: Shutterstock

The 7 best medical smartphone apps

There’s revolution in the air, and it's called Wi-Fi. Wireless-internet-equipped smartphones like iPhones, BlackBerrys and Palms are more than just new variations on your trusty pager or your cell: smartphones are changing the way some physicians practice.

"Times have changed in the PDA world,” says Dr Paul Arnold, a Toronto emergency physician who used to edit the Medical Palm Review. The difference now? On-the-go internet access via Wi-Fi or 3G networking.

"It definitely has changed the way we do medicine," says Vancouver family medicine resident Jessica Otte. "I can get the information I need right away."

How are these plugged-in doctors using their smartphones in clinical settings to save time and improve patient care? Parkhurst Exchange spoke to clinicians from across Canada and overseas to find the best applications.

1. Epocrates. Without equal among mobile pharmacopeias, and by consensus the most useful app around, Epocrates provides detailed prescribing information at your fingertips. Even though it doesn’t list some Canadian formulations and is missing a few OTC drugs, it puts a library’s-worth of reliable, constantly updated drug information right in your pocket. (; all platforms; basic version free, expanded version US$159/year)

on the Parkhurst Exchange website.

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THE INTERVIEW: Dr Bonnie Henry, H1N1 flu fighter

In this month's issue of Parkhurst Exchange, which should be arriving on physicians' desks across the country right about now, you'll find a short Q&A with Dr Bonnie Henry (right), the BC Centre for Disease Control’s director of Public Health Emergency Management the author of the new book Soap and Water & Common Sense: The Definitive Guide to Viruses, Bacteria, Parasites, and Disease (Anansi).

Online, you can read the full version of the interview, in which we discuss the severity of this pandemic, the steps family physicians can take to make their waiting rooms safer, special billing codes for H1N1 flu consults, and the interesting and pertinent story behind how Canada decided to manufacture its own vaccines after the 1976 swine flu, among other things.

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