Learn about Erectile Dysfunction and Sildenafil Citrate Online

Have you ever wondered how sildenafil acts within your body to help you solve your problems with erectile dysfunction?  Thanks to the instant availability of the Internet and computer devices, you will now be able to learn about ED and sildenafil citrate online right at your fingertips.

If you are curious as to how PDE5 inhibitors such as sildenafil work inside your body, then you can browse on search engines by simply typing in the search box the words sildenafil citrate online.  When you read about the mechanics of the action of sildenafil citrate online, you will learn that it helps protect the enzyme cGMP (short for cyclic guanosine monophosphate) from being degraded by the cGMP-specific PDE5 (short for phosphodiesterase type 5 enzyme) which are evidently located in the penile corpus cavernosum of men.  The free radical NO (short for nitric oxide) found in the penile corpus cavernosum adheres itself to what are called the guanylate cyclase receptors, which then results to the occurrence of elevated amounts of cGMP, thereby leading to the vasodilation or relaxation of the smooth muscles of the inner lining cushions of the helicine arteries (tendril-like arteries of the penis importantly involved in the process of its erection).  Once the smooth muscles relax, it will result to vasodilation and therefore there will be an increased supply of blood flowing into the penile spongy tissue, and the end result would be a successful penile erection.

Additionally, what you would also learn about sildenafil citrate online is that its special molecular makeup is somewhat similar to cGMP (located in the penile corpus cavernosum as well) and functions as an aggressive binding element of PDE5 in the penile corpus cavernosum, which results to more concentrations of cGMP and even better occurrences of erections. Avery important information that men will learn through reading about sildenafil citrate online is that sildenafil will be rendered useless without the introduction of one or more sexual stimuli, since only a sexual stimulus will be the only factor that can initiate the activation of the nitric oxide and cGMP inside a man’s body. Read more…

The future of statin therapy

Use in normal-cholesterol patients is on the horizon — will over-the-counter be next?

The most frequently prescribed drug class in Canada may soon become much, much more popular.

AstraZeneca has filed an application with Health Canada to add a new indication for its drug rosuvastatin (Crestor). The application, filed late last year and still under review, asks that rosuvastatin be licensed for use in older patients with normal cholesterol levels but elevated high-sensitivity C-reactive protein (CRP). If approved, the new indication could potentially result in millions of Canadian patients being put on preventive statin therapy.

Whether or not AstraZeneca’s new application is approved, however, recent research makes it all but certain that statins are well on their way to far wider use in the years to come.

to read the rest of this article on the Parkhurst Exchange website.

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WHO growth charts replace US charts as gold standard

The way we keep track of kids' height and weight is changing.

The Canadian Paediatic Society and the College of Family Physicians of Canada have signed on to a new policy statement (PDF) endorsing the WHO's revised growth charts rather than the American CDC growth charts that have long been in use in this country. The new policy is also published in the February issue of the journal Paediatrics & Child Health.

On the Canadian Paediatric Society's website you can find more information, including a health professional's guide to using the WHO growth charts, a fact sheet for parents, and (soon) copies of the WHO charts specifically designed for Canadian doctors.

What was wrong with the CDC growth charts? Basically, they were outdated: their data were based on the assumption that most babies are fed formula, which may have been true 40 years ago but is not today. In a May 2009 column in Parkhurst Exchange magazine, Dr Richard Haber, an associate professor of pediatrics at McGill University and the Director of the Pediatric Consultation Centre at the Montreal Children’s Hospital, explained the CDC charts' problems:

"The revised [CDC] charts don’t necessarily represent optimal growth in infancy as the population data sets represent periods when most babies were bottle-fed; since 1970, only about 50% of infants were breastfed and of these merely 30% for greater than three months. What’s important to remember is that exclusively breastfed babies will plot higher for their weight in the first 6 months and lower for weight in the 6-12 month period. So they may appear to ‘fall off’ their curve. One other disadvantage is that the CDC curves represent cross-sectional data sets based on chronological age and not pubertal stage, and therefore don’t take into account the pubertal growth spurt."
Visit the PE website to read the rest of Dr Haber's May 2009 column, "," and its June 2009 follow-up on spotting red flags in growth data, "."

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